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Regenerative medicine for brain and nerve repair
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We isolated and propagated neural stem cells from the exposed brain tissue of the patients with open brain trauma, and then implanted neural stem cells with MRI-guided stereotactic device for the patients. Within 2-years follow-ups, the patients were investigated for functional recovery. Contrast to the case control group, implantation of neural stem cells was associated with a significant improvement in patient's neurological function. Investigations of stem cell therapy have required analysis of the fate and migration of implanted neural stem cells. Here, We demonstrate the feasibility of labeling human neural stem cells and retinal stem cells with nanoparticle and tracking of implanted cells in monkey and human central nervous system (CNS). This data demonstrates the possibility of stem cell therapy in CNS and collectively provide necessary foundation for overcoming challenges to the enhancement of translational regenerative medicine of brain and optic nerve injury.
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讲师介绍
  • 讲师:朱剑虹(教授)

    教育部长江学者,复旦大学特聘教授, 复旦大学医学神经生物学国家重点实验室副主任,复旦大学附属华山医院神经外科教授。他曾在德国柏林洪堡大学获得细胞生物学博士学位和在苏州大学医学院取得神经外科博士学位。 朱剑虹教授长期从事神经外科和神经生物学临床、研究和教学工作,尤其在神经干细胞生物学、神经损伤修复和中枢神经系统肿瘤方面作了深入研究。先后主持了国家基础研究计划(973项目)课题,上海市科委重大研究项目的研究和国家自然科学基金项目。