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表观遗传学:为什么你的DNA是不够的
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在他的视频第一,Allis博士介绍了表观遗传学的概念; 细胞表型的变化,不是由于DNA突变但由于蛋白质的化学修饰,导致基因的变化在基因激活。在细胞核内,DNA缠绕在组蛋白形成染色质。包装的染色质的紧密程度决定了基因是活动的还是积极或不。这个开关之间的“开和关”状态的染色质是由组蛋白的化学修饰调节。都是描述工作从他的实验室和其他确定的酶:删除和识别组蛋白修饰。组蛋白修饰的变化可能会导致一些疾病,包括可以基因突变与表观遗传修饰的关键区别是,表观遗传改变是可逆的,使他们一个有吸引力的药物靶标。
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讲师介绍
  • 讲师:C. David Allis(博士后研究员)

    Allis收到了他的学士学位在生物学从辛辛那提大学和他的来自印第安那大学的生物学博士,他是一个博士后研究员在罗切斯特大学。C. David Allis的喜悦和Jack Fishman教授的实验室,对在rockefell染色质生物学和表观遗传学实验室主任和洛克菲勒大学的表观遗传学。艾利斯实验室研究如何修饰组蛋白,包装DNA的蛋白质,影响基因表达和这些变化对人类疾病的影响。