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蛋白折叠的传染病和癌症中的蛋白质折叠
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第1A,Lindquist博士解释了蛋白质的折叠问题。蛋白质离开核糖体是长的,氨基酸的线性链但他们需要折叠成复杂的三维形状在非常细胞质的拥挤环境。由于蛋白质错误折叠可以是灾难性的细胞,蛋白质被称为热休克蛋白(HSP)已经发展到促进适当的蛋白质折叠。Lindquist解释说,有时候热休克反应变得不平衡导致人类疾病。在癌症的情况下,热休克蛋白帮助癌细胞生存的压力通常会杀死他们。相反,许多神经退行性疾病,是由于蛋白质错误折叠和聚集表明,在这些疾病,热休克蛋白应没有活性。酵母有许多与人类相同的细胞过程包括对蛋白质折叠和防止蛋白质聚集。部分1b,Lindquist描述如何在酵母中的基因筛选帮助科学家确定突变这增加了形成类似于那些发现的聚集体在神经退行性疾病。另外一个屏幕在酵母中的500000种化学物质确定了一些化合物防止蛋白质聚集。从这两个实验的结果已被验证在小鼠和人类神经元模型。
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