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病毒与宿主细胞表面结合的方式 - Ari Helenius P1
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本视频由科普中国和生物医学大讲堂出品

Ari Helenius (ETH Zurich) Part 1: Virus entry

Viruses are extremely simple and small yet they are responsible for many of the worlds diseases. A virus particle consists of only a genome, a protein coat or capsid, and sometimes a surrounding lipid envelope. To replicate, a virus must successfully enter a host cell, uncoat its genome, and appropriate the host cell machinery to replicate its genome and produce viral proteins. Part 1 of this lecture will discuss ways in which viruses bind to the surface of host cells. Simian Virus 40 which binds to specific cell surface glycolipids, and Human Papilloma Virus-16 which binds to sites on filoipodia, are examples of different binding mechanisms. Attachment of viruses to the plasma membrane activates cell signaling resulting in endocytosis of the viral particles. This lecture is appropriate for upper level undergraduate and graduate classes studying virology or endocytosis.
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讲师介绍
  • 讲师:Ari Helenius(Professor of Biochemistry)

    Ari Helenius has been full Professor of Biochemistry at the ETH Zurich since 1 November 1997. He is currently the head of several interdisciplinary projects in the field of protein folding and virus-cell interaction.