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酵母蛋白分泌途径的研究
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Randy Schekman (Berkeley) Part 1: Studying Protein Secretion in Yeast

Protein secretion is executed by a cellular pathway involving the delivery of membrane and soluble secretory proteins in vesicles that capture newly-synthesized proteins assembled in the endoplasmic reticulum (ER) and sorted in the Golgi apparatus. Vesicles fuse with the plasma membrane resulting in the discharge of soluble molecules to the cell exterior and integration of vesicle membrane proteins and lipids in the cell surface. Baker's yeast cells grow by vesicle fusion and secretion at the tip of the daughter bud. A genetic dissection of this process was performed with temperature sensitive conditional mutants blocked at one of several stations in the secretory pathway. See more athttp://www.ibioseminars.org
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  • 讲师:兰迪·谢克曼(化学家)

    兰迪·韦恩·谢克曼,美国细胞生物学家,加州大学伯克利分校教授,曾任《美国国家科学院院刊》主编。 1992年当选美国国家科学院院士。2002年与詹姆斯·罗思曼因对细胞膜传输的研究获拉斯克基础医学奖。2013年获得诺贝尔生理学或医学奖。