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抗原提呈和树突状细胞 - Ira Mellman Part 2
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本视频由科普中国和生物医学大讲堂出品

早在100多年前,科学家就已经发现,免疫反应是由先天性和适应性免疫两个系统构成。而负责连接这两部分免疫反应的细胞类型,是最近才发现的树突状细胞。树突状细胞具有检测保守微生物产物的能力,可以激活细胞的先天免疫反应,并捕捉到广泛多样的微生物抗原抗体,也可以激活适应性免疫反应。抗原提呈和树突状细胞的独特能力,反映了细胞生物学的一系列显著的特化作用。

Ira Mellman (Genentech) Part 2: Antigen Presentation and Dendritic Cells

The immune response integrates two distinct systems of innate and adaptive immunity discovered over 100 years ago. Linking these two arms of the immune response is the task of a comparatively recently identified cell type, the dendritic cell. Dendritic cells have the capacity to detect the conserved microbial products that activate cells of the innate immune response and capture the dramatically wider diversity of microbial antigens to prime antibody and T cell responses characteristic of adaptive immunity. The unique capacity of dendritic cells for antigen processing and presentation reflects a series of remarkable specializations of basic principles of cell biology.

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