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老年痴呆症基因
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随着全世界人口的不断老齡化,患老年痴呆症的人数正变得越来越多。该讲座按照以下这3方面来谈老年痴呆症: 1,老年痴呆症的发病情况; 2,4个主要老年痴呆症的相关基因和这4个基因与老年痴呆症的关系; 3,已知的β淀粉样多肽导致老年痴呆症的部分致病机理。 老年痴呆症是一种慢性的、神经退行性疾病。病人主要的表现是:刚开始的时候,记忆力衰退;随后,语言出现问题、认知出现问题;再发展到生活不能自理,最终死亡。解剖患老年痴呆症而死亡的病人的大脑,主要可以看到两种病变: 1,大脑当中有大量的老年斑(senile plaque),其中主要成份是β淀粉样蛋白(β amyloid)沉淀; 2,出现神经元纤维缠结(neurofibrillary tangle); 同时,大脑出现明显的萎缩。希望不久的将来,能有针对老年痴呆症的药物上市。
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