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粘着蛋白的发现和表征 - Mary Beckerle P2
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本视频由科普中国和生物医学大讲堂出品

Mary Beckerle (University of Utah) Part 2: Discovery and Characterization

In the second segment, I describe the identification of the focal adhesion protein, zyxin, by my lab. Recent work revealed that zyxin is down-regulated upon expression of the Ewing sarcoma oncoprotein, EWS-FLI. Loss of zyxin expression results in enhanced cell motility and is also associated with failed apoptotic signaling. Evidence that zyxin shuttles between focal adhesions and the nucleus is presented. The impact of reduced zyxin expression on tumor progression is discussed. See more at http://www.ibiology.org
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讲师介绍
  • 讲师:Mary Beckerle(PhD)

    has served as CEO and Director of Huntsman Cancer Institute (HCI) at the University of Utah since 2006, and she was appointed in 2009 to an additional key health sciences leadership role as Associate Vice President for Cancer Affairs at the Universit