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miRNA生物信息学及其在医学研究中的应用
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miRNA是一类重要的基因调控因子,越来越多的证据表明miRNA在许多重要的生命过程中发挥着关键作用。因此,和miRNA有关的功能异常和许多疾病有关(根据人类miRNA疾病数据库, HMDD, http://cmbi.bjmu.edu.cn/hmdd, 的统计,目前已经有近400种人类疾病被报道了和miRNA有关)。因此,miRNA正在成为理解疾病发生发展机制的明星分子,并且疾病的预防、诊断与治疗中具有巨大的潜在的应用价值。从有关miRNA研究的一开始,生物信息学在其中就发挥着重要作用。从miRNA发现到靶基因预测,从分子进化到网络调控,从疾病易感位点确定到疾病miRNA关联分析,都可以看到生物信息学的身影。在本报告中,报告人将重点介绍本人实验室在miRNA-疾病-药物之间关系的生物信息学研究,从大规模数据分析到建模和预测,同时概括miRNA生物信息学在医学研究中的应用。
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