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上皮细胞凋亡:挤压死亡
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上皮细胞是如何死亡的,而不是在保护膜上留下一个洞?在2部分,Rosenblatt解释了她的实验室发现上皮细胞间挤压或挤压死亡细胞的过程中的上皮单单层。1-磷酸鞘氨醇(S1P)是由细胞释放和挤压刺激周围细胞形成肌动球蛋白环。环的收缩挤出的凋亡细胞。有趣的是,拥挤可以激活细胞的活细胞,一旦他们死了,他们失去与其他细胞的接触。Rosenblatt的实验室发现,活,挤压细胞也释放S1P。S1P释放调节由相同的拉伸激活的信道,piezo1,是细胞分裂。这些数据提供了一种机制,上皮屏障功能保持恒定的细胞密度。
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