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神经退行性疾病:帕金森病
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在2部分,Petsko研究帕金森病,最常见的神经退行性疾病后,Petsko和他的同事们研究阿尔茨海默氏症。对帕金森病遗传易感性的患者进行了研究发现在α-突触核蛋白基因的突变导致蛋白的错误折叠和聚集。在帕金森的情况下偶尔发生的,他们发现,α-突触核蛋白的裂解和由此产生的蛋白片段碎片形成聚集体。切换到酵母作为一个模型系统,然后人类细胞,Petsko的实验室鉴定为蛋白酶caspase-1的责任劈α-突触核蛋白。有趣的是,Caspase-1激活期间的影响为头部损伤和脑部感染提供了一个可能的解释可能是帕金森的。Caspase-1抑制剂的发展这可以穿透大脑的希望对帕金森病的有效治疗。
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讲师介绍
  • 讲师:Gregory Petsko(博士)

    Gregory Petsko在脑神经科学教授Arthur J. Mahon和威尔康奈尔医学院心理研究所。他的实验室研究蛋白质的结构和功能,特别侧重于了解和开发治疗或预防性治疗的年龄对于与年龄有关的神经退行性疾病。 Petsko接受了他的学士学位从普林斯顿大学。他被授予罗德奖学金,完成了他的博士。来自牛津大学的David Chilton Phillips爵士的实验室里学习Petsko是委员美国国家科学院和医学院,并获得了许多其他荣誉和奖。