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细胞焦亡信号通路的关键蛋白和研究动态
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细胞焦亡是近年来受到广泛关注的一种炎性细胞程序性细胞死亡,主要通过炎症小体介导包含Caspase-1在内的多种Caspase的激活,造成包括GSDMD在内的多种Gasdermin家族成员发生剪切和多聚化,造成细胞穿孔,进而引起细胞死亡。细胞焦亡与其他多种细胞程序性死亡形式之间存在相互联系和转化,共同构成细胞程序性死亡的复杂体系,维持细胞和机体的内稳态。
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