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循环血微小RNA在诊断急性心肌梗死中的应用前景
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随着我国经济的发展和人民生活水平的提高、饮食结构和环境因素的改变,以血管功能失衡为病理学基础的心脑血管疾病的发病率呈逐年上升趋势,对我国人民群众健康构成了极大威胁。

最近研究表明,多种miRNA参与了胚胎发育、心血管疾病发生、肿瘤发生等生理病理进程。MiRNA在不同组织中具有不同的表达谱,在循环血中并具有较高的稳定性。各种组织在不同原因引起的损伤时,循环血中miRNA含量会发生相应的改变,有可能在相关疾病的发生发展中作为分子标志物。

我们在研究中发现,心肌特异的miR-208a能够作为心肌缺血的血清标志物,具有较高的灵敏性和特异性。血管损伤及随后由其引起的重塑在冠心病、高血压等心脑血管疾病中也发挥重要作用,研究表明循环血miRNA也具备作为血管损伤重塑相关疾病的血清标志物的潜在价值。
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