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陶永光:染色质重塑与肿瘤代谢
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介绍了肿瘤细胞糖代谢重编程-“瓦伯格”效应,延胡索酸和琥珀酸积累致瘤机制。NF-Kb信号的经典途径和非经典途径等。
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讲师介绍
  • 讲师:陶永光(教授)

    中南大学肿瘤研究所 以代谢重编程、肿瘤干细胞和炎症与微环境等为切入点,围绕以染色质修饰致瘤机理进行深入的研究,剖析染色质修饰蛋白LSH致瘤的染色质修饰机制。从基因表达调控、转录因子、信号转导、迁移与转移和放射敏感性等多角度,在分子、细胞、模式动物和人等多个层次进行重要基因的功能及其机制研究,同时建立这些疾病的动物模型用于肿瘤预防与药物筛选,为预防和治疗人类癌症提供诊断/预后的分子标志物以及治疗靶标。