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异常上皮细胞挤压引起的病理改变
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异位上皮细胞挤压与疾病: 当上皮挤压调节出错,疾病,如哮喘或癌症可以导致。在她的第三讲,Rosenblatt描写了上皮疾病如哮喘或癌症可能会导致异常细胞挤压。太多的细胞挤压会导致上皮细胞和细胞的孔妥协的屏障功能,如在哮喘。面向对象的小的挤压会导致大量的细胞聚集在上皮细胞表面上,一个过程可能在一些癌症的工作。Rosenblatt还介绍了工作从她的实验室打乱了S1P信可能引起上皮来源的癌中发挥关键作用,如胰腺胰腺癌。她还解释说,从基底面挤压可能是推动癌症转移的重要的第一步。
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讲师介绍
  • 讲师:Jody Rosenblatt(博士)

    Jody Rosenblatt博士获得学士学位,以优异的成绩从加利福尼亚大学,伯克利和Chiron公司,在经过一个短暂的,她搬到海湾去当一名David Morgan的技术员在加利福尼亚大学,三藩。他在加州大学博士学位期间在提姆Mitchison实验室工作。然后她搬到伦敦大学学院进行博士后培训。这是UCL,Rosenblatt发现挤压其作用在上皮内稳态。 目前,他是在一个部门的副教授肿瘤科学在犹他大学医学院和的Huntsman癌症研究所。她的实验室研究上皮细胞的细胞死亡和分裂。