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端粒和端粒酶在人类干细胞和癌症中的作用 - Elizabeth Blackburn P2
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本视频由科普中国和生物医学大讲堂出品

Elizabeth Blackburn (UCSF) Part 2: Telomeres and Telomerase in Human Stem Cells and in Cancer

Telomerase, a specialized ribonucleprotein reverse transcriptase, is important for long-term eukaryotic cell proliferation and genomic stability, because it replenishes the DNA at telomeres. Thus depending on cell type telomerase partially or completely (depending on cell type) counteracts the progressive shortening of telomeres that otherwise occurs. Telomerase is highly active in many human malignancies, and a potential target for anti-cancer approaches. Furthermore, recent collaborative studies have shown the relationship between accelerated telomere shortening and life stress and that low telomerase levels are associated with six prominent risk factors for cardiovascular disease.
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讲师介绍
  • 讲师:Elizabeth Blackburn(分子生物学家)

    生于澳大利亚、现居美国,拥有澳、美两国国籍,现任加利福尼亚大学旧金山分校生物化学与生物物理学系教授。她是端粒和端粒酶研究领域的先驱,并因在该领域的贡献而与格雷德和绍斯塔克一起获得2009年诺贝尔生理学或医学奖。