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杜祥:医院生物样本库的建设和管理
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生物样本是科研工作的原油,不可替代、不可再生。一方面样本在不断流失、另一方面样本却异常匮乏。生物样本库的出现给生物医药研究和转化医学研究带来了生机,“样本”成为备受关注的对象。医院生物样本库的建设包括“收什么、怎么收、经费来源、样本属于谁、各利益方的平衡、伦理道德”等一系列问题需要面对。

样本库的管理是需要严格的操作流程来作为保障的,建立样本库SOPs是至关重要的一步。样本的质量是样本的灵魂,没有质量的样本给研究结果带来的负面影响要在相当长的时间内才能够消除。质量控制体现在很多方面,包括对取材处理各个环节时间记录、形态复检、生物大分子稳定性分析等。在建立生物样本库的职业队伍时,对人员的培训成为关键。
生物样本库的样本使用规范、样本共享原则和科研合作是生物样本库日常需要面对的问题。
生物样本库可持续性发展也是在建立样本库之始就需要考虑的重要问题。
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