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在双螺旋:变后生景观发展与疾病
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Allis博士研究发育和疾病中的表观遗传学的作用在他的第二个讲座。组蛋白可以在一些氨基酸改性,特别是赖氨酸,通过添加乙酰或甲基。组合模式这些修饰作用增强或抑制基因表达。Allis描述工作从他的实验室和其他说明组蛋白的突变(例如赖氨酸-蛋氨酸突变)阻止这些修改,因此,影响基因表达。Allis描述工作从他的实验室和其他实验室,这表明变异组蛋白的突变(例如赖氨酸对蛋氨酸的突变)可能阻止这些修改,因此,影响基因表达。可悲的是,这些“原癌蛋白”的基因突变已被确定为导致包括小儿脑肿瘤和胰腺神经内分泌肿瘤。
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讲师介绍
  • 讲师:C. David Allis(博士后研究员)

    Allis收到了他的学士学位在生物学从辛辛那提大学和他的来自印第安那大学的生物学博士,他是一个博士后研究员在罗切斯特大学。C. David Allis的喜悦和Jack Fishman教授的实验室,对在rockefell染色质生物学和表观遗传学实验室主任和洛克菲勒大学的表观遗传学。艾利斯实验室研究如何修饰组蛋白,包装DNA的蛋白质,影响基因表达和这些变化对人类疾病的影响。