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Dr. Shyamal Goswami, PhD

Institut Pasteur of Shanghai Chinese Academy of Sciences

Sam graduated from CNCI in 2012 with Cancer immunology and Immunotherapy. His initial approach in research career was by studying the differentiation and maturation of human dendritic cells to modulate immune functions in cancer. Furthermore in research associate phase in same institute, he extended the interest in immune checkpoints, especially IDO mediated tumor suppression and it’s regulation through DC- Treg crosstalk by down modulation of CTLA4. In 2014, he joined as CAS-President’s initiative postdoctoral fellow in Institut Pasteur of Shanghai (SIBS-CAS) as a member of the lab of Prof. Zhang Xiaoming, PhD. Sam was interested in studying the heterogeneity of tumor across cancer and eventually started multi-dimensional flow cytometric based scanning of human tumors, could be said as immune-cellomics. To this end, he feels the need of in-situ multiplex phenotyping, which might reveal more appropriate biomarker in clinical setup. His recent works have greatly improved the thoughts of multiplex imaging in a combinational approach of 6-8 biomarkers in a single slide to see beyond conventional, coupled with cutting edge digital pathology platform. Currently he is working as associate professor in the same division and his team focused- to expand the library of best available clones, enhanced multiplexing, set up an observer independent digital pathology algorithm and big data analysis hub to enrich the Biomarker research, seems a living revolution in immuno-oncology based combination therapy. Thus, his visionary is to develop immune landscape mapping in pan cancer approach to provide key information to the clinician to optimize treatment modalities.
演讲题目:Multiplex Multispectral Imaging and Digital Pathology: An Emerging Perspective in Immuno- Oncology Research

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